tax free cigarettes
2007-09-15
The exposure of cells to smoke in culture requires model systems with trade-offs. The fact that smoke extracts differ from "routine" smoke is a limitation. However, in vivo cells are not exposed to "smoke," but rather to components of smoke that have been extracted into biological fluids. Reductionist approaches that evaluate defined concentrations of specific components present in smoke are also problematic. Although the toxicity of individual components can be assessed, it is likely that the biological response to complex mixtures such as cheap cigarettes smoke is not the sum of multiple independent toxicities. In vitro assays, using some type of smoke preparation, will, without doubt, remain important tools in the assessment of cigarette smoke–induced toxicity. In vitro cell culture studies using cigarettes online smoke extracts are likely to remain useful model systems.[ Back to top ]
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